الكلية: كلية العلوم- قسم الكيمياء
الجهة البحثية: الجامعة الأردنية
ع نوان البحث المنشور:
Thiophene ring-opening reactions II. Easy synthesis of 1,3,4-thiadiazoline-sulfanylpyridazine hybrids
حقل البحث: العلوم الأساسية
سنة النشر: 2021
ملخص البحث المنشور:
The reaction of N′-arylbenzothiohydrazides with 1-aryl-6-chloro-5-nitro-4-oxothieno[2,3-c]pyridazine-3-carboxylic ester, in the presence of triethylamine, proceeded via a thiophene ring-opening process and furnished, upon addition of iodomethane or allyl bromide, the respective 6-(methyl/allylthio)-4-oxopyridazine-1,3,4-thiadiazoline hybrids. Acid-catalyzed hydrolysis of the latter esters yielded the corresponding carboxylic acids. The new compounds were characterized by IR, HRMS, and NMR spectral data, and the 4-oxopyridazine-thiadiazoline structures confirmed by X-ray crystallography for a representative hybrid of the set.
رابط البحث المنشور :
https://link.springer.com/article/10.1007/s00706-021-02798-4